The real cancer fight begins

Good evening to all our friends and family.

And so the real cancer fight begins. You might ask what? Chiane has already been in treatment for 9 months. That is true, but we only dealt with the symptoms. We treated the lump, and for now the cancer is at bay. We did not treat the cause of her cancer. Find the cause, treat the cause, and you cure the cancer. Getting rid of the tumour is far from winning the battle. What started the cancer to grow in the first place?

For those of you that have walked this journey with is from day one, will remember that we had Chiane’s gene’s tested privately by a 3rd party gene research center last year September. The gene report stated that Chiane has a lot of cancer genes active in her body, and “anti cancer genes” that are switched off. The P53 gene is at the heart of the problem as it is not even detectable in Chiane.

The tumour removed last year during her brain operations was also tested for 2 specific proteins. If these 2 proteins were present in her tumour, the
cause could be one of many, but because these proteins were not found in her tumour, it means only one thing…that there is a genetic link
to her cancer”.

Taken in to account the findings of the tumour, her genes that was analysed, and our family history with cancer, it appears we have a case of the Li-Fraumeni Syndrome as quoted by GOSH.

What is Li-Fraumeni syndrome?

Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults. By greatly I mean 5000 times more likely to develop cancer. One of the most common cancers include brain tumors, cancers of blood-forming tissues (leukemias), and a cancer called adrenocortical carcinoma that affects the outer layer of the adrenal glands (small hormone-producing glands on top of each kidney). Several other types of cancer also occur more frequently in people with Li-Fraumeni syndrome like breast cancer.

The CHEK2 and TP53 genes are associated with Li-Fraumeni syndrome.

TP53 is a tumor suppressor gene, which means that it normally helps control the growth and division of cells. Mutations in this gene can allow cells to divide in an uncontrolled way and form tumors. What does this mean in English? In a very simple way, the best way to explain it is… Your body makes new cells ever day, and cells divide/split in 2 constantly. The P53 gene monitors the division of cells, and sometimes when cells split, it is abnormal, the P53 gene kills it off. The P53 gene is the police gene making sure all cells are healthy in the body. If this gene doesn’t work, it means abnormal cells that develop in your body are not being detected, and it starts growing sufficient to develop cancer…. This gene is currently not working in Chiane’s body…meaning the risk of her cancer coming back and relapsing are very high.

There is further concerns about Estian, Chiane’s 3 year old brother.  Estian was tested and he already show 4 markers showing abnormality in his genes. In plain English? Estian is at high risk of  developing cancer in the next 24 months because of a high volume of abnormal cell growth in his body.

The real fight for Chiane’s life only begins now. Although Estian doesn’t have cancer yet, he will follow her path if we don’t sort him out as well. It’s not a matter of “if”, but “when”

What is the good news? …the real cancer fight begins now. We know what is wrong with Chiane, and we can sort Estian out before he develops cancer. This is an extremely positive position to be in. We are fortune enough to have this information. We can now focus on a long term solution to prevent Chiane from relapsing, and prevent Estian from developing cancer and go through the same journey his sister did.

We are now starting “to fight the good fight”!


Posted on May 3, 2012, in News from Chris. Bookmark the permalink. Comments Off on The real cancer fight begins.

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